Evaluation of salivary α-L-Fucose and its related parameters in periodontitis
Background and objective: Periodontitis is one of the most widespread oral diseases in Kurdistan. Saliva can be used as a noninvasive diagnostic fluid to measure chemical biomarkers released during oral disease, so this work is directed to focus on the study of salivary fucose (a glycoprotein component) and its related parameters in periodontitis, to assess the possibility of using them as indicators for the disease and its progress.
Methods: The present work included 79 individuals. They were grouped into healthy (32), advanced periodontitis (20) and moderate periodontitis(27) subjects. Their age was ranged between (20-60) years. Unstimulated whole saliva samples were collected from all the groups. The samples were used for the estimation of salivary; total fucose (TF), protein bound fucose (PBF), protein bound hexose (PBH), lipid associated fucose (LAF), total protein (TP), total calcium (TCa), zinc (Zn), and salivary magnesium (Mg).
Results: Salivary TF, LAF, FF, PBF, TP and TCa were significantly increased in both advanced and moderate periodontic groups comparing to healthy individuals, while there were no significant differences in salivary PBH, Mg and Mg/Ca levels in periodontic groups when compared to normal. Salivary TF/TP, PBF/TP, PBH/TP and FF/TP ratios and salivary zinc were significantly reduced in periodontic males.
Conclusion: On the basis of the above results, it can be concluded that these biochemical parameters, may be used as indicators for the extent of periodontal tissue damage, thus they can be used in the identification of periodontitis progresses and treatment follow up.
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