Taman Mahdi Hamed
Medical Research Center
Medical Research Center
Mechanisms of defective insulin secretion in type 2 diabetes
Papers have published in peer-review international journals with High Thomson Reuters Impact factor. Papers presented in the international conferences, Symposium and Workshop
Rosengren AH, Braun M, Mahdi T, Andersson SA, Travers ME, Shigeto M, Zhang E, Almgren P, Ladenvall C, Axelsson AS, Edlund A, Pedersen MG, Jonsson A, Ramracheya R, Tang Y, Walker JN, Barrett A, Johnson PR, Lyssenko V, McCarthy MI, Groop L, Salehi A, Gloyn AL, Renström E, Rorsman P, Eliasson L. Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes. Diabetes. 2012 Jul;61(7):1726-33
Mahdi T, Hänzelmann S, Salehi A, Muhammed SJ, Reinbothe TM, Tang Y, Axelsson AS, Zhou Y, Jing X, Almgren P, Krus U, Taneera J, Blom AM, Lyssenko V, Esguerra JL, Hansson O, Eliasson L, Derry J, Zhang E, Wollheim CB, Groop L, Renström E, Rosengren AH. Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes. Cell Metab. 2012 Nov 7;16(5):625-33.
Mahdi T, Mecham B, Groop L, Renström E and Rosengren AH. A module of co-expressed genes in human islets associated with type 2 diabetes and islet dedifferentiation. Manuscript.
Pawel Buda, Thomas Reinbothe, Vini Nagaraj, Taman Mahdi, Cheng Luan, Yunzhao Tang, Annika S. Axelsson, Daiqing Li, Anders H. Rosengren, Erik Renström and Enming Zhang. Eukaryotic translation initiation factor 3 subunit E controls intracellular calcium homeostasis by regulation of CaV1.2 surface ex
pression. PLoS One 2013
P Buda, E Zhang, T Mahdi, T Reinbothe, E Renstrom .The Cav1. 2 calcium channel spatial ex
pression in pancreatic beta cells is regulated by eIF3e-eukaryotic translation initiation factor subunit'e.DIABETOLOGIA 54, S112-S112.2011
E Zhang, P Buda, T Mahdi, T Reinbothe, J Striessnig, E Renström . Activity-Dependent Cav1. 2 Cluster Surface ex
pressions in Insulin-SecretingCell . Biophysical Journal 98 (3), 695a 2010
P Buda, T Reinbothe, T Mahdi, E Renstrom. elF3e controls pancreatic beta-cell proliferation and apoptosis by regulation of CaV1. 2 calcium ion channel surface ex
Jan 2009- Feb 2013 Academy of Graduate studies, Ph.D. Medical Science,
Experimental Diabetes Mellitus
Clinical Research Center (CRC), Lund University
Nov 1998- June 2004 Bachelor Medicine and General Surgery (M.B.Ch.B.)
Salahaddin University (current Hawler Medical University)
2004-2006 As a junior house officer (internship) in department of internal medicine and department of general surgery in Erbil-Rezgary hospital, Hawler teaching hospital, Erbil-Emergency hospital and department of Gynecology and obstetrics and department of pediatrics in Maternity and pediatric hospital /Kurdistan-Erbil.
2007-2008 General Practitioner (GP) in Shaqlawa Hospital
2008-2009 Permanent of internal medicine in Erbil-Rezgary hospital, Hawler teaching hospital
Feb 2013-Feb.2014 Postdoc
Lund University, Department of Clinical Science, , Sewed.
Nov 2011-present Lecturer
Hawler Medical Unoversity,Medical Research Center. Hawler, KRG, Iraq
Insulin secretion and content measurement in vitro( from human and rodent islets and cell line)
Islet and cell line viability assessment
Cell membrane capacitance recording (Patch Clamp technique)
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